Publicazioni

2018

– Baldassarro VA, Marchesini A, Facchinetti F, Villetti G, Calzà L, Giardino L. Cell death in pure-neuronal and neuron-astrocyte mixed primary culture subjected to oxygen-glucose deprivation: The contribution of poly(ADP-ribose) polymerases and caspases. Microchem J, 2018, 136:215-222

2017

– Baldassarro VA, Marchesini A, Giardino L, Calzà L, Vulnerability to oxygen-glucose deprivation of primary neurons derived from Tg2576 Alzheimer mice: role of intraneuronal Abeta accumulation and astrocytes. Disease Models & Mechanisms, 2017, 10:671-678.

– Calzà L., Baldassarro VA, Fernandez M., Giuliani A., Lorenzini L., Giardino L. Thyroid hormone and the white matter of the central nervous system: from development to repair. Vitamins&Hormones, 2017 in press

– Stagni F, Raspanti A, Giacomini A, Guidi S, Emili M, Ciani E, Giuliani A, Bighinati A, Calzà L, Magistretti J, Bartesaghi R. Long-term effect of neonatal inhibition of APP gamma-secretase on hippocampal development in the Ts65Dn mouse model of Down syndrome. Neurobiol Dis. 2017, 103:11-23.

– Baldassarro VA, Marchesini A, Giardino L, Calzà L. PARP activity and inhibition in fetal and adult oligodendrocyte precursor cells: effect on cell survival and differentiation. Stem Cell Research, 2017 22:54-60

– Pannella M, Giardino L., Calzà L, Fernández M, Growth and Neurotrophic Factors in Embryonic Stem Cells, Methods in Molecular Biology, 2017 in press

2016

– Lorenzini L, Giuliani A, Sivilia S, Baldassarro VA, Fernandez M, Margotti ML, Giardino L, Fontani V, Rinaldi S, Calzà L. REAC technology modifies pathological neuroinflammation and motor behaviour in an Alzheimer’s disease mouse model. Sci Rep 2016, 6:37483 PMID:27857200

– Borjini N, Fernández M, Giardino L, Calzà L. Cytokine and chemokine alterations in tissue, CSF, and plasma in early presymptomatic phase of experimental allergic encephalomyelitis (EAE), in a rat model of multiple sclerosis. J Neuroinflammation 2016, 13:291 PMID:27846891

– Rubagotti S, Croci S, Ferrari E, Iori M, Capponi PC, Lorenzini L, Calzà L, Versari A, Asti M. Int J Mol Sci 2016, 17(9) pii: E1480 PMID:27608011

– Baldassarro VA, Dolci LS, Mangano C, Giardino L, Gualandi C, Focarete ML, Calzà L. In Vitro Testing of Biomaterials for Neural Repair: Focus on Cellular Systems and High-Content Analysis. Biores Open Access 2016, 5:201-11 PMID:27588220

– Fernández M, Baldassarro VA, Sivilia S, Giardino L, Calzà L. Inflammation severely alters thyroid hormone signaling in the central nervous system during experimental allergic encephalomyelitis in rat: Direct impact on OPCs differentiation failure. Glia 2016, 64:1573-89 PMID:27404574

– Sivilia S, Mangano C, Beggiato S, Giuliani A, Torricella R, Baldassarro VA, Fernandez M, Lorenzini L, Giardino L, Borelli AC, Ferraro L, Calzà L. CDKL5 knockout leads to altered inhibitory transmission in the cerebellum of adult mice. Genes Brain Behav 2016, 15(5):491-502 PMID:27108663

– Borroto-Escuela DO, Wydra K, Pintsuk J, Narvaez M, Corrales F, Zaniewska M, Agnati LF, Franco R, Tanganelli S, Ferraro L, Filip M, Fuxe K. Understanding the Functional Plasticity in Neural Networks of the Basal Ganglia in Cocaine Use Disorder: A Role for Allosteric Receptor-Receptor Interactions in A2A-D2 Heteroreceptor Complexes. Neural Plast 2016 PMID:27872762

– Barbieri M, Ossato A, Canazza I, Trapella C, Borelli AC, Beggiato S, Rimondo C, Serpelloni G, Ferraro L, Marti M. Synthetic cannabinoid JWH-018 and its halogenated derivatives JWH-018-Cl and JWH-018-Br impair Novel Object Recognition in mice: Behavioral, electrophysiological and neurochemical evidence. Neuropharmacology 2016, 109:254-69 PMID:27346209

– Borroto-Escuela DO, Pintsuk J, Schäfer T, Friedland K, Ferraro L, Tanganelli S, Liu F, Fuxe K.  Multiple D2 heteroreceptor complexes: new targets for treatment of schizophrenia.Ther Adv Psychopharmacol 2016, 6:77-94 PMID:27141290

– Beggiato S, Tomasini MC, Borelli AC, Borroto-Escuela DO, Fuxe K, Antonelli T, Tanganelli S, Ferraro L. Functional role of striatal A2A, D2, and mGlu5 receptor interactions in regulating striatopallidal GABA neuronal transmission. J Neurochem 2016, 138(2):254-64 PMID:27127992

– Ferraro L, Tiozzo Fasiolo L, Beggiato S, Borelli AC, Pomierny-Chamiolo L, Frankowska M, Antonelli T, Tomasini MC, Fuxe K, Filip M. Neurotensin: A role in substance use disorder? J Psychopharmacol 2016, 30:112-27 PMID:26755548

– Chiodi V, Ferrante A, Ferraro L, Potenza RL, Armida M, Beggiato S, Pèzzola A, Bader M, Fuxe K, Popoli P, Domenici MR. Striatal adenosine-cannabinoid receptor interactions in rats over-expressing adenosine A2A receptors. J Neurochem 2016, 136:907-17 PMID:26526685

Tomasini MC, Borelli AC, Beggiato S, Tanganelli S, Loche A, Cacciaglia R, Ferraro L, Antonelli T. GET73 Prevents Ethanol-Induced Neurotoxicity in Primary Cultures of Rat Hippocampal Neurons. Alcohol Alcohol 2016, 51:128-35 PMID:26271115

2015

– Rinaldi S, Calzà L, Giardino L, Biella GE, Zippo AG, Fontani V. Radio electric asymmetric conveyer: a novel neuromodulation technology in Alzheimer’s and other neurodegenerative diseases. Front Psychiatry 2015, 6:22 • PMID:25741289

– Zaniboni A, Bernardini C, Bertocchi M, Zannoni A, Bianchi F, Avallone G, Mangano C, Sarli G, Calzà L, Bacci ML, Forni M. In vitro differentiation of porcine aortic vascular precursor cells to endothelial and vascular smooth muscle cells. Am J Physiol Cell Physiol. 2015, 309:C320-31 PMID:26135800

– Calzà L, Fernández M, Giardino L. Role of the Thyroid System in Myelination and Neural Connectivity. Compr Physiol. 2015, 5:1405-21 PMID:26140723

– Tomasini MC, Borelli AC, Beggiato S, Ferraro L, Cassano T, Tanganelli S, Antonelli T. Differential Effects of Palmitoylethanolamide against Amyloid-β Induced Toxicity in Cortical Neuronal and Astrocytic Primary Cultures from Wild-Type and 3xTg-AD Mice. J Alzheimers Dis 2015 •  PMID:25765918

– Giuliani A, Lorenzini L, Alessandri M, Torricella R, Baldassarro VA, Giardino L, Calzà L. In vitro exposure to very low-level laser modifies expression level of extracellular matrix protein RNAs and mitochondria dynamics in mouse embryonic fibroblasts. BMC Complement Altern Med. 2015, 15:78 PMID:25886934

– Porrini V, Lanzillotta A, Branca C, Benarese M, Parrella E, Lorenzini L, Calzà L, Flaibani R, Spano PF, Imbimbo BP, Pizzi M. CHF5074 (CSP-1103) induces microglia alternative activation in plaque-free Tg2576 mice and primary glial cultures exposed to beta-amyloid. Neuroscience 2015, 302:112-20 • PMID:25450955

2014

– Rinaldi S, Calzà L, Giardino L, Biella GE, Zippo AG, Fontani V. Radio electric asymmetric conveyer: a novel neuromodulation technology in Alzheimer’s and other neurodegenerative diseases. Front Psychiatry 2015, 6:22 • PMID:25741289

– Tomasini MC, Borelli AC, Beggiato S, Ferraro L, Cassano T, Tanganelli S, Antonelli T. Differential Effects of Palmitoylethanolamide against Amyloid-β Induced Toxicity in Cortical Neuronal and Astrocytic Primary Cultures from Wild-Type and 3xTg-AD Mice. J Alzheimers Dis 2015 •  PMID:25765918

– Porrini V, Lanzillotta A, Branca C, Benarese M, Parrella E, Lorenzini L, Calzà L, Flaibani R, Spano PF, Imbimbo BP, Pizzi M. CHF5074 (CSP-1103) induces microglia alternative activation in plaque-free Tg2576 mice and primary glial cultures exposed to beta-amyloid. Neuroscience 2014 • PMID:25450955

– Paradisi M, Alviano F, Pirondi S, Lanzoni G, Fernandez M, Lizzo G, Giardino L, Giuliani A, Costa R, Marchionni C, Bonsi L, Calza L. Human mesenchymal stem cells produce bioactive neurotrophic factors: source, individual variability and differentiation issues. Int J Immunopathol Pharmacol 2014, 27:391-402 • PMID:25280030

– Alessandri M, Lizzo G, Gualandi C, Mangano C, Giuliani A, Focarete ML, Calzà L. Influence of biological matrix and artificial electrospun scaffolds on proliferation, differentiation and trophic factor synthesis of rat embryonic stem cells. Matrix Biology 2014, 33:68-76 • PubMed

– Fuchs C, Trazzi S, Torricella R, Viggiano R, De Franceschi M, Amendola E, Gross C, Calzà L, Bartesaghi R, Ciani E. Loss of CDKL5 impairs survival and dendritic growth of newborn neurons by altering AKT/GSK-3β signaling. Neurobiol Dis 2014  PMID:24952363

– Branca C, Sarnico I, Ruotolo R, Lanzillotta A, Viscomi AR, Benarese M, Porrini V, Lorenzini L, Calzà L, Imbimbo BP, Ottonello S, Pizzi M. Pharmacological targeting of the β-amyloid precursor protein intracellular domain. Sci Rep 2014, 4:4618  PMID:24714650

– Beggiato S, Giuliani A, Sivilia S, Lorenzini L, Antonelli T, Imbimbo BP, Giardino L, Calzà L, Ferraro L. CHF5074 and LY450139 sub-acute treatments differently affect cortical extracellular glutamate levels in pre-plaque Tg2576 mice. Neuroscience 2014, 266:13-22  PMID:24530449

– Guidi S, Stagni F, Bianchi P, Ciani E, Giacomini A, De Franceschi M, Moldrich R, Kurniawan N, Mardon K, Giuliani A, Calzà L, Bartesaghi R. Prenatal pharmacotherapy rescues brain development in a Down’s syndrome mouse model. Brain 2014, 137:380-401 PMID:24334313

– Zaniboni A, Bernardini C, Alessandri M, Mangano C, Zannoni A, Bianchi F, Sarli G, Calzà L, Bacci ML, Forni M. Cells derived from porcine aorta tunica media show mesenchymal stromal-like cell properties in in vitro culture. Am J Physiol Cell Physiol 2014, 306:C322-33  PMID:24304832

– Beggiato S, Antonelli T, Tomasini MC, Borelli AC, Agnati LF, Tanganelli S, Fuxe K, Ferraro L. Adenosine A2A-D2 receptor-receptor interactions in putative heteromers in the regulation of the striato-pallidal gaba pathway: possible relevance for parkinson’s disease and its treatment. Curr Protein Pept Sci 2014, 15:673-80  PMID:25175458

– Ferraro L, Beggiato S, Borroto-Escuela DO, Ravani L, O’Connor WT, Tomasini MC, Borelli AC, Agnati LF, Antonelli T, Tanganelli S, Fuxe K. Neurotensin NTS1-dopamine D2 receptor-receptor interactions in putative receptor heteromers: relevance for Parkinson’s disease and schizophrenia. Curr Protein Pept Sci 2014, 15:681-90  PMID:25175457

– Ferrante A, Martire A, Pepponi R, Varani K, Vincenzi F, Ferraro L, Beggiato S, Tebano MT, Popoli P. Expression, pharmacology and functional activity of adenosine A1 receptors in genetic models of Huntington’s disease. Neurobiol Dis 2014, 71:193-204  PMID:25132555

– Dalpiaz A, Ferraro L, Perrone D, Leo E, Iannuccelli V, Pavan B, Paganetto G, Beggiato S, Scalia S. Brain uptake of a Zidovudine prodrug after nasal administration of solid lipid microparticles. Mol Pharm 2014, 11:1550-61  PMID:24717116

– Beggiato S, Tanganelli S, Fuxe K, Antonelli T, Schwarcz R, Ferraro L. Endogenous kynurenic acid regulates extracellular GABA levels in the rat prefrontal cortex. Neuropharmacology 2014, 82:11-8  PMID:24607890

– Zamberletti E, Beggiato S, Steardo L Jr, Prini P, Antonelli T, Ferraro L, Rubino T, Parolaro D. Alterations of prefrontal cortex GABAergic transmission in the complex psychotic-like phenotype induced by adolescent delta-9-tetrahydrocannabinol exposure in rats. Neurobiol Dis 2014, 63:35-47  PMID:24200867

2013

– Guidi S, Stagni F, Bianchi P, Ciani E, Ragazzi E, Trazzi S, Grossi G, Mangano C, Calzà L, Bartesaghi R. Early pharmacotherapy with fluoxetine rescues dendritic pathology in the Ts65Dn mouse model of Down syndrome. Brain Pathol. 2013, 23:129-43 • PubMed 

– Imbimbo BP, Frigerio E, Breda M, Fiorentini F, Fernandez M, Sivilia S, Giardino L, Calzà L, Norris D, Casula D, Shenouda M. Pharmacokinetics and Pharmacodynamics of CHF5074 After Short-term Administration in Healthy Subjects. Alzheimer Disease and Associated Disorders, 2013, 27:278-86 • PubMed 

– Giuliani A, Beggiato S, Baldassarro AV, Mangano C, Giardino L, Imbimbo BP, Antonelli T, Calzà L, Ferraro L. CHF5074 restores visual memory ability and presynaptic cortical acetylcholine release in pre-plaque Tg2576 mice. J Neurochem. 2013, 124:613-20 • PubMed

– Salvati S, Di Biase A, Attorri L, Di BenedettoR., Sanchez M, Lorenzini L., Alessandri M., Calzà L. Ethyl-Eicosapentaenoic Acid Ameliorates The Clinical Course of Experimental Allergic Encephalomyelitis Induced in Dark-Agouti Rats J Nutr Biochem, 2013, 24:1645-54 • PubMed

– Brandi G, de Rosa F, Calzà L, Girolamo SD, Tufoni M, Ricci CS, Cirignotta F, Caraceni P, Biasco G. Can the tyrosine kinase inhibitors trigger metabolic encephalopathy in cirrhotic patients? Liver Int. 2013, 33:488-93. • PubMed

– Guidi S, Stagni F, Bianchi P, Ciani E, Ragazzi E, Trazzi S, Grossi G, Mangano C, Calzà L. Bartesaghi R. Pharmacotherapy with Fluoxetine Restores Functional Connectivity from the Dentate Gyrus to Field CA3 in the Ts65Dn Mouse Model of Down Sindrome PlosOne, 2013, 8:e61689 • PubMed

– Sivilia S, Lorenzini L, Giuliani A, Gusciglio M, Fernandez M, Baldassarro VA, Mangano C, Ferraro L, Pietrina V, Baroc MF, Viscomi R, Ottonello S, Villetta G, Imbimbo BP, Calza L, Giardino L. Multi-Target Action of the novel anti-Alzheimer compound CHF5074: In vivo study of long term treatment in Tg2576 Mice, BMC Neuroscience, 2013, 14:44-58. • PubMed

– Ross J, Sharma S, Winston J, Nunez M, Bottini G, Franceschi M, Scarpini E, Frigerio E, Fiorentini F, Fernandez M, Sivilia S, Giardino L, Calzà L, Norris D, Cicirello H, Casula D, Imbimbo BP. CHF5074 reduces biomarkers of neuroinflammation in patients with mild cognitive impairment: a 12-week, double-blind, placebo-controlled study. Current Alzheimer Research, 2013, 10:742-53. • PubMed

– Calzà L, Baldassarro VA, Giuliani A, Lorenzini L, Fernandez M, Mangano C, Sivilia S, Alessandri M, Gusciglio M, Torricella R, Giardino L. From the multifactorial nature of AD to multitarget therapy: the contribution of the translational approach. Current Topics in Medicinal Chemistry, 2013, 13:1843-52. • PubMed

– Alessandri M., Lizzo G., Gualandi C., Mangano C., Giuliani A., Focarete M.L., Calzà L. Influence of biological matrix and artificial electrospun scaffolds on proliferation, differentiation and trophic factor synthesis of rat embryonic stem cells. Matrix Biology, 2013, in press, doi:pii: S0945-053X(13)00105-4. 10.1016/j.matbio.2013.08.001. [Epub ahead of print] • PubMed

– Baldassarro VA, Lizzo G, Paradisi M, Fernandez M, Giardino L, Calzà L. Neural stem cells isolated from amyloid precursor protein-mutated mice: a tool for in vitro studies and drug discovery Word Journal on Stem Cells, 2013, 5:229-37 • PubMed

– Pori M, Galletti P, Soldati R, Calzà L, Mangano C, Giacomini D. Azetidinone-retinoid hybrids: synthesis and differentiative effects. Eur J Med Chem, 2013, 70:857-63 • PubMed

– Guidi S, Stagni F, Bianchi P, Ciani E, Giacomini A, De Franceschi M, Moldrich R, Kurniawan N, Mardon K, Giuliani A, Calzà L, Bartesaghi R. Prenatal pharmacotherapy rescues brain development in a Down syndrome model Brain, 2013, in press • PubMed

– Dolci LS, Quiroga SD, Gherardi M, Laurita R, Liguori A, Ghedini E, Sanibondi P, Fiorani A, Calzà L, Colombo V, Focarete ML. Carboxyl surface functionalization of poly(L-lactic acid) electrospun nanofibers through atmospheric non-thermal plasma affects fibroblast morphological response Plasma Processes and Polymers, 2013, in press – Zaniboni A, Bernardini C, Alessandri M, Mangano C, Zannoni A, Bianchi F, Sarli G, Calzà L, Bacci ML, Forni M. Cells derived from porcine aorta tunica media show mesenchymal stromal-like cell properties in in vitro culture. Am J Physiol Cell Physiol. 2013 Dec 4. [Epub ahead of print] • PubMed

2012

 – Dell’Acqua ML, Lorenzini L, D’Intino G, Sivilia S, Pasqualetti P, Panetta V, Paradisi M, Filippi MM, Baiguera C, Pizzi M, Giardino L, Rossini PM, Calzà L (2012) Functional and molecular evidence of myelin- and neuroprotection by thyroid hormone administration in experimental allergic encephalomyelitis. Neuropathol. Appl. Neurobiol. 38:454-70. • PubMed

– Ferraro L, Beggiato S, Tomasini MC, Fuxe K, Antonelli T, Tanganelli S (2012) A(2A)/D(2) receptor heteromerization in a model of Parkinson’s disease. Focus on striatal aminoacidergic signaling. Brain Res. 1476:96-107. • PubMed

– Ferraro L, Frankowska M, Marcellino D, Zaniewska M, Beggiato S, Filip M, Tomasini MC, Antonelli T, Tanganelli S, Fuxe K (2012) A novel mechanism of cocaine to enhance dopamine d2-like receptor mediated neurochemical and behavioral effects. An in vivo and in vitro study. Neuropsychopharmacology 37:1856-66. • PubMed

– Frye CA, Bo E, Calamandrei G, Calzà L, Dessì-Fulgheri F, Fernández M, Fusani L, Kah O, Kajta M, Le Page Y, Patisaul HB, Venerosi A, Wojtowicz AK, Panzica GC (2012) Endocrine disrupters: a review of some sources, effects, and mechanisms of actions on behaviour and neuroendocrine systems. J. Neuroendocrinol. 24:144-59. • PubMed

– Massella A, D’Intino G, Fernández M, Sivilia S, Lorenzini L, Giatti S, Melcangi RC, Calzà L, Giardino L (2012) Gender effect on neurodegeneration and myelin markers in an animal model for multiple sclerosis. BMC Neurosci 13:12. • PubMed

– Tanganelli S, Antonelli T, Tomasini MC, Beggiato S, Fuxe K, Ferraro L (2012) Relevance of dopamine D(2)/neurotensin NTS1 and NMDA/neurotensin NTS1 receptor interaction in psychiatric and neurodegenerative disorders. Curr. Med. Chem.19:304-16. • PubMed

– Tomasini MC, Beggiato S, Ferraro L, Tanganelli S, Marani L, Lorenzini L, Antonelli T (2012) Prenatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin produces alterations in cortical neuron development and a long-term dysfunction of glutamate transmission in rat cerebral cortex. Neurochem. Int. 61:759-66. • PubMed

2011

 – Balducci C, Mehdawy B, Mare L, Giuliani A, Lorenzini L, Sivilia S, Giardino L, Calzà L, Lanzillotta A, Sarnico I, Pizzi M, Usiello A, Viscomi AR, Ottonello S, Villetti G, Imbimbo BP, Nisticò G, Forloni G, Nisticò R (2011) The ?-secretase modulator CHF5074 restores memory and hippocampal synaptic plasticity in plaque-free Tg2576 mice. J. Alzheimers Dis. 24:799-816. • PubMed

– Baratto L, Calzà L, Capra R, Gallamini M, Giardino L, Giuliani A, Lorenzini L, Traverso S (2011) Ultra-low-level laser therapy. Lasers Med Sci 26:103-12. • PubMed

– Boero C, Carrara S, Del Vecchio G, Calzà L, De Micheli G (2011) Highly sensitive carbon nanotube-based sensing for lactate and glucose monitoring in cell culture.IEEE Trans Nanobioscience 10:59-67. • PubMed

– Colombo G, Lorenzini L, Zironi E, Galligioni V, Sonvico F, Balducci AG, Pagliuca G, Giuliani A, Calzà L, Scagliarini A (2011) Brain distribution of ribavirin after intranasal administration. Antiviral Res. 92:408-14. • PubMed

 – D’Intino G, Lorenzini L, Fernandez M, Taglioni A, Perretta G, Del Vecchio G, Villoslada P, Giardino L, Calzà L (2011) Triiodothyronine administration ameliorates the demyelination/remyelination ratio in a non-human primate model of multiple sclerosis by correcting tissue hypothyroidism. J. Neuroendocrinol. 23:778-90. • PubMed

 – Fernández M, Pirondi S, Chen BL, Del Vecchio G, Alessandri M, Farnedi A, Pession A, Feki A, Jaconi ME, Calzà L (2011) Isolation of rat embryonic stem-like cells: a tool for stem cell research and drug discovery. Dev. Dyn. 240:2482-94. • PubMed

 – Ferraro L, Beggiato S, Tomasini MC, Antonelli T, Loche A, Tanganelli S (2011) GET73 modulates rat hippocampal glutamate transmission: evidence for a functional interaction with mGluR5. Pharmacol Rep 63:1359-71. • PubMed

 – Ferraro L, Beggiato S, Tomasini MC, Fuxe K, Tanganelli S, Antonelli T (2011) Neurotensin regulates cortical glutamate transmission by modulating N-methyl-D-aspartate receptor functional activity: an in vivo microdialysis study. J. Neurosci. Res. 89:1618-26. • PubMed

2010

 – Calzà L, Fernandez M, Giardino L (2010) Cellular approaches to central nervous system remyelination stimulation: thyroid hormone to promote myelin repair via endogenous stem and precursor cells. J. Mol. Endocrinol. 44:13-23. • PubMed

– Castaldo P, Magi S, Cataldi M, Arcangeli S, Lariccia V, Nasti AA, Ferraro L, Tomasini MC, Antonelli T, Cassano T, Cuomo V, Amoroso S (2010) Altered regulation of glutamate release and decreased functional activity and expression of GLT1 and GLAST glutamate transporters in the hippocampus of adolescent rats perinatally exposed to Delta(9)-THC. Pharmacol. Res. 61:334-41. • PubMed

– Fernández M, Paradisi M, D’Intino G, Del Vecchio G, Sivilia S, Giardino L, Calzà L (2010) A single prenatal exposure to the endocrine disruptor 2,3,7,8-tetrachlorodibenzo-p-dioxin alters developmental myelination and remyelination potential in the rat brain. J. Neurochem. 115:897-909. • PubMed

– Ferraro L, Beggiato S, Marcellino D, Frankowska M, Filip M, Agnati LF, Antonelli T, Tomasini MC, Tanganelli S, Fuxe K (2010) Nanomolar concentrations of cocaine enhance D2-like agonist-induced inhibition of the K+-evoked [3H]-dopamine efflux from rat striatal synaptosomes: a novel action of cocaine. J Neural Transm 117:593-7. • PubMed

– Imbimbo BP, Giardino L, Sivilia S, Giuliani A, Gusciglio M, Pietrini V, Del Giudice E, D’Arrigo A, Leon A, Villetti G, Calzà L (2010) CHF5074, a novel gamma-secretase modulator, restores hippocampal neurogenesis potential and reverses contextual memory deficit in a transgenic mouse model of Alzheimer’s disease. J. Alzheimers Dis. 20:159-73. • PubMed

– Lorenzini L, Giuliani A, Giardino L, Calzà L (2010) Laser acupuncture for acute inflammatory, visceral and neuropathic pain relief: An experimental study in the laboratory rat. Res. Vet. Sci. 88:159-65. • PubMed

– Paradisi M, Fernández M, Del Vecchio G, Lizzo G, Marucci G, Giulioni M, Pozzati E, Antonelli T, Lanzoni G, Bagnara GP, Giardino L, Calzà L (2010) Ex vivo study of dentate gyrus neurogenesis in human pharmacoresistant temporal lobe epilepsy.Neuropathol. Appl. Neurobiol. 36:535-50. • PubMed

– Pirondi S, Giuliani A, Del Vecchio G, Giardino L, Hökfelt T, Calzà L (2010) The galanin receptor 2/3 agonist Gal2-11 protects the SN56 cells against beta-amyloid 25-35 toxicity. J. Neurosci. Res. 88:1064-73. • PubMed

2009

 – Del Vecchio G, Giuliani A, Fernandez M, Mesirca P, Bersani F, Pinto R, Ardoino L, Lovisolo GA, Giardino L, Calzà L (2009) Effect of radiofrequency electromagnetic field exposure on in vitro models of neurodegenerative disease. Bioelectromagnetics30:564-72. • PubMed

– Del Vecchio G, Giuliani A, Fernandez M, Mesirca P, Bersani F, Pinto R, Ardoino L, Lovisolo GA, Giardino L, Calzà L (2009) Continuous exposure to 900MHz GSM-modulated EMF alters morphological maturation of neural cells. Neurosci. Lett.455:173-7. • PubMed

– Fernández M, Paradisi M, Del Vecchio G, Giardino L, Calzà L (2009) Thyroid hormone induces glial lineage of primary neurospheres derived from non-pathological and pathological rat brain: implications for remyelination-enhancing therapies. Int. J. Dev. Neurosci. 27:769-78. • PubMed

– Ferraro L, Tomasini MC, Beggiato S, Guerrini R, Salvadori S, Fuxe K, Calzà L, Tanganelli S, Antonelli T (2009) Emerging evidence for neurotensin receptor 1 antagonists as novel pharmaceutics in neurodegenerative disorders. Mini Rev Med Chem 9:1429-38. • PubMed

– Giuliani A, Lorenzini L, Gallamini M, Massella A, Giardino L, Calzà L (2009) Low infra red laser light irradiation on cultured neural cells: effects on mitochondria and cell viability after oxidative stress. BMC Complement Altern Med 9:8. • PubMed

– Massella A, Gusciglio M, D’Intino G, Sivilia S, Ferraro L, Calzà L, Giardino L (2009) Gabapentin treatment improves motor coordination in a mice model of progressive ataxia. Brain Res. 1301:135-42. • PubMed

2008

 – Ferraro L, Tomasini MC, Mazza R, Fuxe K, Fournier J, Tanganelli S, Antonelli T (2008) Neurotensin receptors as modulators of glutamatergic transmission. Brain Res Rev58:365-73. • PubMed

– Sivilia S, Giuliani A, Del Vecchio G, Giardino L, Calzà L (2008) Age-dependent impairment of hippocampal neurogenesis in chronic cerebral hypoperfusion.Neuropathol. Appl. Neurobiol. 34:52-61. • PubMed

– Sivilia S, Paradisi M, D’Intino G, Fernandez M, Pirondi S, Lorenzini L, Calzà L (2008) Skin homeostasis during inflammation: a role for nerve growth factor. Histol. Histopathol. 23:1-10. • PubMed

2007

 – Antonelli T, Fuxe K, Tomasini MC, Mazzoni E, Agnati LF, Tanganelli S, Ferraro L (2007) Neurotensin receptor mechanisms and its modulation of glutamate transmission in the brain: relevance for neurodegenerative diseases and their treatment. Prog. Neurobiol. 83:92-109. • PubMed

– Antonelli T, Tomasini MC, Fuxe K, Agnati LF, Tanganelli S, Ferraro L (2007) Receptor-receptor interactions as studied with microdialysis. Focus on NTR/D2 interactions in the basal ganglia. J Neural Transm 114:105-13. • PubMed

– Emgård M, Paradisi M, Pirondi S, Fernandez M, Giardino L, Calzà L (2007) Prenatal glucocorticoid exposure affects learning and vulnerability of cholinergic neurons.Neurobiol. Aging 28:112-21. • PubMed

– Pirondi S, D’Intino G, Gusciglio M, Massella A, Giardino L, Kuteeva E, Ogren SO, Hökfelt T, Calzà L (2007) Changes in brain cholinergic markers and spatial learning in old galanin-overexpressing mice. Brain Res. 1138:10-20. • PubMed

2006

 – Antonelli T, Fuxe K, Agnati L, Mazzoni E, Tanganelli S, Tomasini MC, Ferraro L (2006) Experimental studies and theoretical aspects on A2A/D2 receptor interactions in a model of Parkinson’s disease. Relevance for L-dopa induced dyskinesias. J. Neurol. Sci. 248:16-22. • PubMed

– D’Intino G, Perretta G, Taglioni A, Calistri M, Falzone C, Baroni M, Giardino L, Calzà L (2006) Endogenous stem and precursor cells for demyelinating diseases: an alternative for transplantation? Neurol. Res. 28:513-7. • PubMed

2005

 – Antonelli T, Fuxe K, Tomasini MC, Bartoszyk GD, Seyfried CA, Tanganelli S, Ferraro L (2005) Effects of sarizotan on the corticostriatal glutamate pathways. Synapse58:193-9. • PubMed

– Calzà L, Fernandez M, Giuliani A, D’Intino G, Pirondi S, Sivilia S, Paradisi M, Desordi N, Giardino L (2005) Thyroid hormone and remyelination in adult central nervous system: a lesson from an inflammatory-demyelinating disease. Brain Res. Brain Res. Rev. 48:339-46. • PubMed

– D’Intino G, Paradisi M, Fernandez M, Giuliani A, Aloe L, Giardino L, Calzà L (2005) Cognitive deficit associated with cholinergic and nerve growth factor down-regulation in experimental allergic encephalomyelitis in rats. Proc. Natl. Acad. Sci. U.S.A.102:3070-5. • PubMed

– Fernandez M, Pirondi S, Antonelli T, Ferraro L, Giardino L, Calzà L (2005) Role of c-Fos protein on glutamate toxicity in primary neural hippocampal cells. J. Neurosci. Res. 82:115-25. • PubMed

– Pirondi S, Fernandez M, Schmidt R, Hökfelt T, Giardino L, Calzà L (2005) The galanin-R2 agonist AR-M1896 reduces glutamate toxicity in primary neural hippocampal cells.J. Neurochem. 95:821-33. • PubMed

– Pirondi S, Kuteeva E, Giardino L, Ferraro L, Antonelli T, Bartfai T, Ogren SO, Hökfelt T, Calzà L (2005) Behavioral and neurochemical studies on brain aging in galanin overexpressing mice. Neuropeptides 39:305-12. • PubMed

2004

 – Antonelli T, Ferraro L, Fuxe K, Finetti S, Fournier J, Tanganelli S, De Mattei M, Tomasini MC (2004) Neurotensin enhances endogenous extracellular glutamate levels in primary cultures of rat cortical neurons: involvement of neurotensin receptor in NMDA induced excitotoxicity. Cereb. Cortex 14:466-73. • PubMed

– Calzà L, Fernandez M, Giuliani A, Pirondi S, D’Intino G, Manservigi M, De Sordi N, Giardino L (2004) Stem cells and nervous tissue repair: from in vitro to in vivo. Prog. Brain Res. 146:75-91. • PubMed

– Calzà L, Giardino L (2004) Neuroprotection: a realistic goal for aged brain? Adv. Exp. Med. Biol. 541:153-68. • PubMed

– Fernandez M, Giuliani A, Pirondi S, D’Intino G, Giardino L, Aloe L, Levi-Montalcini R, Calzà L (2004) Thyroid hormone administration enhances remyelination in chronic demyelinating inflammatory disease. Proc. Natl. Acad. Sci. U.S.A. 101:16363-8. • PubMed

– Fernandez M, Pirondi S, Manservigi M, Giardino L, Calzà L (2004) Thyroid hormone participates in the regulation of neural stem cells and oligodendrocyte precursor cells in the central nervous system of adult rat. Eur. J. Neurosci. 20:2059-70. • PubMed

– Giardino L, Giuliani A, Fernandez M, Calzà L (2004) Spinal motoneurone distress during experimental allergic encephalomyelitis. Neuropathol. Appl. Neurobiol.30:522-31. • PubMed

– Giuliani A, D’Intino G, Paradisi M, Giardino L, Calzà L (2004) p75(NTR)-immunoreactivity in the subventricular zone of adult male rats: expression by cycling cells. J. Mol. Histol. 35:749-58. • PubMed

– Giuliani A, Fernandez M, Farinelli M, Baratto L, Capra R, Rovetta G, Monteforte P, Giardino L, Calzà L (2004) Very low level laser therapy attenuates edema and pain in experimental models. Int J Tissue React 26:29-37. • PubMed

– Tanganelli S, Sandager Nielsen K, Ferraro L, Antonelli T, Kehr J, Franco R, Ferré S, Agnati LF, Fuxe K, Scheel-Krüger J (2004) Striatal plasticity at the network level. Focus on adenosine A2A and D2 interactions in models of Parkinson’s Disease.Parkinsonism Relat. Disord. 10:273-80. • PubMed

2003

 – Calzà L, Fernandez M, Giuliani A, Pirondi S, D’Intino G, Giardino L (2003) Nerve growth factor in the central nervous system: more than neuron survival. Arch Ital Biol 141:93-102. • PubMed

– Calza L, Giuliani A, Fernandez M, Pirondi S, D’Intino G, Aloe L, Giardino L (2003) Neural stem cells and cholinergic neurons: regulation by immunolesion and treatment with mitogens, retinoic acid, and nerve growth factor. Proc. Natl. Acad. Sci. U.S.A.100:7325-30. • PubMed

2002

 – Antonelli T, Tomasini MC, Finetti S, Giardino L, Calzà L, Fuxe K, Soubriè P, Tanganelli S, Ferraro L (2002) Neurotensin enhances glutamate excitotoxicity in mesencephalic neurons in primary culture. J. Neurosci. Res. 70:766-73. • PubMed

– Calza L, Fernandez M, Giuliani A, Aloe L, Giardino L (2002) Thyroid hormone activates oligodendrocyte precursors and increases a myelin-forming protein and NGF content in the spinal cord during experimental allergic encephalomyelitis. Proc. Natl. Acad. Sci. U.S.A. 99:3258-63. • PubMed

– Díaz-Cabiale Z, Fuxe K, Narváez JA, Finetti S, Antonelli T, Tanganelli S, Ferraro L (2002) Neurotensin-induced modulation of dopamine D2 receptors and their function in rat striatum: counteraction by a NTR1-like receptor antagonist. Neuroreport13:763-6. • PubMed

– Giardino L, Giuliani A, Battaglia A, Carfagna N, Aloe L, Calza’ L (2002) Neuroprotection and aging of the cholinergic system: a role for the ergoline derivative nicergoline (Sermion). Neuroscience 109:487-97. • PubMed

– Giardino L, Giuliani A, Bettelli C, Calzà L (2002) Thyroid hormone and retinoids affect motoneuron phenotype and reaction after axotomy in the spinal cord of adult rats.Brain Res. 925:122-32. • PubMed

– Giardino L, Zanni M, Fernandez M, Battaglia A, Pignataro O, Calzà L (2002) Plasticity of GABA(a) system during ageing: focus on vestibular compensation and possible pharmacological intervention. Brain Res. 929:76-86. • PubMed

2001

 – Ferraro L, Tomasini MC, Fernandez M, Bebe BW, O’Connor WT, Fuxe K, Glennon JC, Tanganelli S, Antonelli T (2001) Nigral neurotensin receptor regulation of nigral glutamate and nigroventral thalamic GABA transmission: a dual-probe microdialysis study in intact conscious rat brain. Neuroscience 102:113-20. • PubMed

2000

 – Giardino L, Bettelli C, Calzà L (2000) In vivo regulation of precursor cells in the subventricular zone of adult rat brain by thyroid hormone and retinoids. Neurosci. Lett. 295:17-20. • PubMed

– Giardino L, Giuliani A, Calzà L (2000) Exogenous administration of L-arginine protects cholinergic neurons from colchicine neurotoxicity. Neuroreport 11:1769-72. • PubMed

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